Scientific Data

Design of DiabaSens®:

DiabaSens® was created by a scientist who is a leader in the formulation of topical and transdermal pharmaceuticals. Dr. Bassam Damaj developed a wide range of popular and effective health and personal care products. DiabaSens® patent-pending formula is the result of extensive research into the optimal combination of natural oils to activate the specific channels in the skin to increase sensitivity and ingredients like L-Arginine and L-Citrulline to potentially increase blood flow to the most needed areas affected by many ailments.

Ingredients of DiabaSens®:

DiabaSens® is a blend of amino acids, essential oils and natural botanicals including coriander oil, cinnamon bark oil, L-Arginine, L-Citrulline and other extracts. Those ingredients in DiabaSens® are listed as FDA-GRAS (generally recognized as safe). DiabaSens® is manufactured in the United States in an FDA-registered GMP (Good Manufacturing Practices) facility to ensure quality and consistency.

Mechanism of Action of and Proven Results of DiabaSens®:

The four main ingredients of DiabaSens® (cinnamon oil, coriander oil, L-Arginine and L-Citrulline) works by activating the Transient Receptor Potential A1 (TRPA-1) channels, increase nitric oxide production and inducing changes to the membrane of bacteria.

1. TRPA1 channels are activated by cinnamon oil (Bandell et al., 2004; Jordt et al., 2004; Bautista et al., 2006) and recent findings have indicated that TRPA1 is involved in mechano-sensation among other actions (Namer et al., 2005; Obata et al., 2005). The mechanism of action is simplified in the figure below. Cinnamon bark oil in DiabaSens® works by activating the TRPA-1 channels responsible for the heat and cold sensation of the skin and results in an increase of sensation that current users welcome and appreciate.

Cinnamaldehyde is the most specific TRPA1 activator and excites a subset of sensory neurons highly enriched in cold-sensitive neurons to elicits nociceptive behavior

Increase in Sensitivity. Cinnamaldehyde present in cinnamon oil increases sensitivity to the skin through exciting the TRPA1 channels.

Dose Concentration Response:

Cinnamaldehyde in the presence or absence of 10 μM ruthenium red (1)

2. L-Arginine and L-Citrulline are natural amino acids found in your body and are very intimately involved in the regulation of nitric oxide playing a major role in vessels relation and blood flow. The body converts L-Arginine to Nitric Oxide (NO), which is necessary to maintain functions to protect endothelial cells that line the entire circulatory system, relax blood vessels and provide better blood flow and better nerve signaling. The body converts L-Arginine and L-Citrulline to Nitric Oxide, which sends a signal for the blood vessels to relax. The relaxation of the blood vessels increases blood flow and improves circulation. Improved circulation leads to better tissue health

3. Damaging the cell wall of bacteria is an effective way to kill it and reduce its numbers (J Med Microbiol. 2011 Oct;60(Pt 10):1479-86. doi: 10.1099/jmm.0.034157-0. Epub 2011 Aug 23). Coriander oil in one of the ingredients in DiabaSens®.